prasugrel metabolite Search Results


prasugrel metabolite  (BOC Sciences)
93
BOC Sciences prasugrel metabolite
Effect of fentanyl on platelet aggregation in whole blood. The influence of 2 or 2000 ng/ml fentanyl on whole blood platelet aggregation was measured in non-stimulated cells ( A ), cells stimulated with 2 µM ADP in combination with fentanyl ( B , C ), and cells stimulated with 5 µM ADP after 15-min preincubation with <t>prasugrel</t> <t>metabolite</t> and fentanyl ( D , E ). Data with normal distribution ( A , C ‒ E ) are expressed as mean ± SD, and those with non-normal distribution ( B ) are given as median with interquartile range, n = 6. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001 vs. control
Prasugrel Metabolite, supplied by BOC Sciences, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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prasugrel metabolite r138727  (BOC Sciences)
91
BOC Sciences prasugrel metabolite r138727
Effect of fentanyl on platelet aggregation in whole blood. The influence of 2 or 2000 ng/ml fentanyl on whole blood platelet aggregation was measured in non-stimulated cells ( A ), cells stimulated with 2 µM ADP in combination with fentanyl ( B , C ), and cells stimulated with 5 µM ADP after 15-min preincubation with <t>prasugrel</t> <t>metabolite</t> and fentanyl ( D , E ). Data with normal distribution ( A , C ‒ E ) are expressed as mean ± SD, and those with non-normal distribution ( B ) are given as median with interquartile range, n = 6. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001 vs. control
Prasugrel Metabolite R138727, supplied by BOC Sciences, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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ticagrelor and prasugrel active metabolite (pam)  (AstraZeneca ltd)
90
AstraZeneca ltd ticagrelor and prasugrel active metabolite (pam)
Effect of fentanyl on platelet aggregation in whole blood. The influence of 2 or 2000 ng/ml fentanyl on whole blood platelet aggregation was measured in non-stimulated cells ( A ), cells stimulated with 2 µM ADP in combination with fentanyl ( B , C ), and cells stimulated with 5 µM ADP after 15-min preincubation with <t>prasugrel</t> <t>metabolite</t> and fentanyl ( D , E ). Data with normal distribution ( A , C ‒ E ) are expressed as mean ± SD, and those with non-normal distribution ( B ) are given as median with interquartile range, n = 6. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001 vs. control
Ticagrelor And Prasugrel Active Metabolite (Pam), supplied by AstraZeneca ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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active metabolite of prasugrel  (Eli Lilly)
90
Eli Lilly active metabolite of prasugrel
Effect of fentanyl on platelet aggregation in whole blood. The influence of 2 or 2000 ng/ml fentanyl on whole blood platelet aggregation was measured in non-stimulated cells ( A ), cells stimulated with 2 µM ADP in combination with fentanyl ( B , C ), and cells stimulated with 5 µM ADP after 15-min preincubation with <t>prasugrel</t> <t>metabolite</t> and fentanyl ( D , E ). Data with normal distribution ( A , C ‒ E ) are expressed as mean ± SD, and those with non-normal distribution ( B ) are given as median with interquartile range, n = 6. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001 vs. control
Active Metabolite Of Prasugrel, supplied by Eli Lilly, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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prasugrel active metabolite  (Alsachim SAS)
90
Alsachim SAS prasugrel active metabolite
Effect of fentanyl on platelet aggregation in whole blood. The influence of 2 or 2000 ng/ml fentanyl on whole blood platelet aggregation was measured in non-stimulated cells ( A ), cells stimulated with 2 µM ADP in combination with fentanyl ( B , C ), and cells stimulated with 5 µM ADP after 15-min preincubation with <t>prasugrel</t> <t>metabolite</t> and fentanyl ( D , E ). Data with normal distribution ( A , C ‒ E ) are expressed as mean ± SD, and those with non-normal distribution ( B ) are given as median with interquartile range, n = 6. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001 vs. control
Prasugrel Active Metabolite, supplied by Alsachim SAS, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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metabolite variation  (Biosynth Carbosynth)
89
Biosynth Carbosynth metabolite variation
Effect of fentanyl on platelet aggregation in whole blood. The influence of 2 or 2000 ng/ml fentanyl on whole blood platelet aggregation was measured in non-stimulated cells ( A ), cells stimulated with 2 µM ADP in combination with fentanyl ( B , C ), and cells stimulated with 5 µM ADP after 15-min preincubation with <t>prasugrel</t> <t>metabolite</t> and fentanyl ( D , E ). Data with normal distribution ( A , C ‒ E ) are expressed as mean ± SD, and those with non-normal distribution ( B ) are given as median with interquartile range, n = 6. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001 vs. control
Metabolite Variation, supplied by Biosynth Carbosynth, used in various techniques. Bioz Stars score: 89/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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prasugrel metabolites  (Daiichi Sankyo)
90
Daiichi Sankyo prasugrel metabolites
Effect of fentanyl on platelet aggregation in whole blood. The influence of 2 or 2000 ng/ml fentanyl on whole blood platelet aggregation was measured in non-stimulated cells ( A ), cells stimulated with 2 µM ADP in combination with fentanyl ( B , C ), and cells stimulated with 5 µM ADP after 15-min preincubation with <t>prasugrel</t> <t>metabolite</t> and fentanyl ( D , E ). Data with normal distribution ( A , C ‒ E ) are expressed as mean ± SD, and those with non-normal distribution ( B ) are given as median with interquartile range, n = 6. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001 vs. control
Prasugrel Metabolites, supplied by Daiichi Sankyo, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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prasugrel's active metabolite  (Eli Lilly)
90
Eli Lilly prasugrel's active metabolite
Effect of fentanyl on platelet aggregation in whole blood. The influence of 2 or 2000 ng/ml fentanyl on whole blood platelet aggregation was measured in non-stimulated cells ( A ), cells stimulated with 2 µM ADP in combination with fentanyl ( B , C ), and cells stimulated with 5 µM ADP after 15-min preincubation with <t>prasugrel</t> <t>metabolite</t> and fentanyl ( D , E ). Data with normal distribution ( A , C ‒ E ) are expressed as mean ± SD, and those with non-normal distribution ( B ) are given as median with interquartile range, n = 6. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001 vs. control
Prasugrel's Active Metabolite, supplied by Eli Lilly, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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pharmacologically active metabolites of prasugrel  (Daiichi Sankyo)
90
Daiichi Sankyo pharmacologically active metabolites of prasugrel
Effect of fentanyl on platelet aggregation in whole blood. The influence of 2 or 2000 ng/ml fentanyl on whole blood platelet aggregation was measured in non-stimulated cells ( A ), cells stimulated with 2 µM ADP in combination with fentanyl ( B , C ), and cells stimulated with 5 µM ADP after 15-min preincubation with <t>prasugrel</t> <t>metabolite</t> and fentanyl ( D , E ). Data with normal distribution ( A , C ‒ E ) are expressed as mean ± SD, and those with non-normal distribution ( B ) are given as median with interquartile range, n = 6. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001 vs. control
Pharmacologically Active Metabolites Of Prasugrel, supplied by Daiichi Sankyo, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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prasugrel r138727 metabolite  (Helm AG)
90
Helm AG prasugrel r138727 metabolite
Effect of fentanyl on platelet aggregation in whole blood. The influence of 2 or 2000 ng/ml fentanyl on whole blood platelet aggregation was measured in non-stimulated cells ( A ), cells stimulated with 2 µM ADP in combination with fentanyl ( B , C ), and cells stimulated with 5 µM ADP after 15-min preincubation with <t>prasugrel</t> <t>metabolite</t> and fentanyl ( D , E ). Data with normal distribution ( A , C ‒ E ) are expressed as mean ± SD, and those with non-normal distribution ( B ) are given as median with interquartile range, n = 6. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001 vs. control
Prasugrel R138727 Metabolite, supplied by Helm AG, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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prasugrel active metabolite (pra-am)  (Toronto Research Chemicals)
90
Toronto Research Chemicals prasugrel active metabolite (pra-am)
Effect of fentanyl on platelet aggregation in whole blood. The influence of 2 or 2000 ng/ml fentanyl on whole blood platelet aggregation was measured in non-stimulated cells ( A ), cells stimulated with 2 µM ADP in combination with fentanyl ( B , C ), and cells stimulated with 5 µM ADP after 15-min preincubation with <t>prasugrel</t> <t>metabolite</t> and fentanyl ( D , E ). Data with normal distribution ( A , C ‒ E ) are expressed as mean ± SD, and those with non-normal distribution ( B ) are given as median with interquartile range, n = 6. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001 vs. control
Prasugrel Active Metabolite (Pra Am), supplied by Toronto Research Chemicals, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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standards of the active and inactive metabolites of prasugrel  (Sankyo Co)
90
Sankyo Co standards of the active and inactive metabolites of prasugrel
Effect of fentanyl on platelet aggregation in whole blood. The influence of 2 or 2000 ng/ml fentanyl on whole blood platelet aggregation was measured in non-stimulated cells ( A ), cells stimulated with 2 µM ADP in combination with fentanyl ( B , C ), and cells stimulated with 5 µM ADP after 15-min preincubation with <t>prasugrel</t> <t>metabolite</t> and fentanyl ( D , E ). Data with normal distribution ( A , C ‒ E ) are expressed as mean ± SD, and those with non-normal distribution ( B ) are given as median with interquartile range, n = 6. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001 vs. control
Standards Of The Active And Inactive Metabolites Of Prasugrel, supplied by Sankyo Co, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


Effect of fentanyl on platelet aggregation in whole blood. The influence of 2 or 2000 ng/ml fentanyl on whole blood platelet aggregation was measured in non-stimulated cells ( A ), cells stimulated with 2 µM ADP in combination with fentanyl ( B , C ), and cells stimulated with 5 µM ADP after 15-min preincubation with prasugrel metabolite and fentanyl ( D , E ). Data with normal distribution ( A , C ‒ E ) are expressed as mean ± SD, and those with non-normal distribution ( B ) are given as median with interquartile range, n = 6. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001 vs. control

Journal: Pharmacological Reports

Article Title: Interactions of fentanyl with blood platelets and plasma proteins: platelet sensitivity to prasugrel metabolite is not affected by fentanyl under in vitro conditions

doi: 10.1007/s43440-023-00447-7

Figure Lengend Snippet: Effect of fentanyl on platelet aggregation in whole blood. The influence of 2 or 2000 ng/ml fentanyl on whole blood platelet aggregation was measured in non-stimulated cells ( A ), cells stimulated with 2 µM ADP in combination with fentanyl ( B , C ), and cells stimulated with 5 µM ADP after 15-min preincubation with prasugrel metabolite and fentanyl ( D , E ). Data with normal distribution ( A , C ‒ E ) are expressed as mean ± SD, and those with non-normal distribution ( B ) are given as median with interquartile range, n = 6. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001 vs. control

Article Snippet: Prasugrel metabolite (R-138727) was obtained from BOC Sciences (Shirley, NY, USA).

Techniques: Control

The effect of fentanyl on ADP-induced platelet aggregation in PRP in the absence and presence of prasugrel metabolite

Journal: Pharmacological Reports

Article Title: Interactions of fentanyl with blood platelets and plasma proteins: platelet sensitivity to prasugrel metabolite is not affected by fentanyl under in vitro conditions

doi: 10.1007/s43440-023-00447-7

Figure Lengend Snippet: The effect of fentanyl on ADP-induced platelet aggregation in PRP in the absence and presence of prasugrel metabolite

Article Snippet: Prasugrel metabolite (R-138727) was obtained from BOC Sciences (Shirley, NY, USA).

Techniques: Control, Incubation

Representative curves of ADP-induced platelet aggregation measured by LTA. The effect of fentanyl on agonist-induced platelet function was measured in PRP, in the absence or presence of 1.3 µM prasugrel metabolite (PM). The example data show platelet response to fentanyl added to PRP with subthreshold concentration of ADP ( A ) or preincubated with PM before stimulation of PRP with 5 µM ADP

Journal: Pharmacological Reports

Article Title: Interactions of fentanyl with blood platelets and plasma proteins: platelet sensitivity to prasugrel metabolite is not affected by fentanyl under in vitro conditions

doi: 10.1007/s43440-023-00447-7

Figure Lengend Snippet: Representative curves of ADP-induced platelet aggregation measured by LTA. The effect of fentanyl on agonist-induced platelet function was measured in PRP, in the absence or presence of 1.3 µM prasugrel metabolite (PM). The example data show platelet response to fentanyl added to PRP with subthreshold concentration of ADP ( A ) or preincubated with PM before stimulation of PRP with 5 µM ADP

Article Snippet: Prasugrel metabolite (R-138727) was obtained from BOC Sciences (Shirley, NY, USA).

Techniques: Concentration Assay

Effect of fentanyl on platelet activation. The influence of 2 or 2000 ng/ml fentanyl on platelet function was measured in blood, PRP or suspensions of isolated platelets in the following models: non-stimulated cells ( A ), cells stimulated with 2 µM ADP in combination with fentanyl ( B ), cells stimulated with 2 µM ADP after 15-min preincubation with fentanyl ( C ), and cells stimulated with 10 µM ADP after 15-min preincubation with prasugrel metabolite and fentanyl ( D ). Data with normal distribution ( A , B : PRP/platelets, C / D : blood/platelets, D : blood/PRP) are expressed as mean ± SD; otherwise data are presented as median with interquartile range, n = 6‒7. Before statistical analysis, data showing departure from normal distribution were log transformed for normalization. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001 vs. the appropriate controls: vehicle ( A ) or ADP ( B ‒ D )

Journal: Pharmacological Reports

Article Title: Interactions of fentanyl with blood platelets and plasma proteins: platelet sensitivity to prasugrel metabolite is not affected by fentanyl under in vitro conditions

doi: 10.1007/s43440-023-00447-7

Figure Lengend Snippet: Effect of fentanyl on platelet activation. The influence of 2 or 2000 ng/ml fentanyl on platelet function was measured in blood, PRP or suspensions of isolated platelets in the following models: non-stimulated cells ( A ), cells stimulated with 2 µM ADP in combination with fentanyl ( B ), cells stimulated with 2 µM ADP after 15-min preincubation with fentanyl ( C ), and cells stimulated with 10 µM ADP after 15-min preincubation with prasugrel metabolite and fentanyl ( D ). Data with normal distribution ( A , B : PRP/platelets, C / D : blood/platelets, D : blood/PRP) are expressed as mean ± SD; otherwise data are presented as median with interquartile range, n = 6‒7. Before statistical analysis, data showing departure from normal distribution were log transformed for normalization. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001 vs. the appropriate controls: vehicle ( A ) or ADP ( B ‒ D )

Article Snippet: Prasugrel metabolite (R-138727) was obtained from BOC Sciences (Shirley, NY, USA).

Techniques: Activation Assay, Isolation, Transformation Assay

Summary of kinetic constants and binding affinities for the interactions of fentanyl and prasugrel metabolite with human plasma proteins assayed by SPR

Journal: Pharmacological Reports

Article Title: Interactions of fentanyl with blood platelets and plasma proteins: platelet sensitivity to prasugrel metabolite is not affected by fentanyl under in vitro conditions

doi: 10.1007/s43440-023-00447-7

Figure Lengend Snippet: Summary of kinetic constants and binding affinities for the interactions of fentanyl and prasugrel metabolite with human plasma proteins assayed by SPR

Article Snippet: Prasugrel metabolite (R-138727) was obtained from BOC Sciences (Shirley, NY, USA).

Techniques: Binding Assay, Clinical Proteomics

Representative SPR sensograms showing the interactions of fentanyl or prasugrel metabolite with HSA, α 1 -AGP, ApoA-1, or ApoB-100. The proteins were immobilized to a dextran-coated gold surface. Injection of analyte (10, 20, 40 80 μM fentanyl or 2, 5, 10 μM prasugrel metabolite) produced a signal change that was directly proportional to the mass of bound drug molecules, expressed in resonance units (RU). Further details are given in

Journal: Pharmacological Reports

Article Title: Interactions of fentanyl with blood platelets and plasma proteins: platelet sensitivity to prasugrel metabolite is not affected by fentanyl under in vitro conditions

doi: 10.1007/s43440-023-00447-7

Figure Lengend Snippet: Representative SPR sensograms showing the interactions of fentanyl or prasugrel metabolite with HSA, α 1 -AGP, ApoA-1, or ApoB-100. The proteins were immobilized to a dextran-coated gold surface. Injection of analyte (10, 20, 40 80 μM fentanyl or 2, 5, 10 μM prasugrel metabolite) produced a signal change that was directly proportional to the mass of bound drug molecules, expressed in resonance units (RU). Further details are given in

Article Snippet: Prasugrel metabolite (R-138727) was obtained from BOC Sciences (Shirley, NY, USA).

Techniques: Injection, Produced